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  <xs:element id="cron_HealthCanadaLicensingAgreementsMember" abstract="true" name="HealthCanadaLicensingAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_IsraeliCodesLicensingAgreementsMember" abstract="true" name="IsraeliCodesLicensingAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_FiniteLivedIntangibleAssetsAccumulatedImpairment" abstract="false" name="FiniteLivedIntangibleAssetsAccumulatedImpairment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IndefiniteLivedIntangibleAssetsGross" abstract="false" name="IndefiniteLivedIntangibleAssetsGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IndefiniteLivedIntangibleAssetsAccumulatedImpairment" abstract="false" name="IndefiniteLivedIntangibleAssetsAccumulatedImpairment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IntangibleAssetsAccumulatedImpairment" abstract="false" name="IntangibleAssetsAccumulatedImpairment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_FiniteLivedIntangibleAssetsAccumulatedImpairmentTranslationAndPurchaseAccountingAdjustments" abstract="false" name="FiniteLivedIntangibleAssetsAccumulatedImpairmentTranslationAndPurchaseAccountingAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IndefiniteLivedIntangibleAssetsAccumulatedImpairmentImpairmentInPeriod" abstract="false" name="IndefiniteLivedIntangibleAssetsAccumulatedImpairmentImpairmentInPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IntangibleAssetsAccumulatedImpairmentImpairmentInPeriod" abstract="false" name="IntangibleAssetsAccumulatedImpairmentImpairmentInPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_IntangibleAssetsAccumulatedImpairmentTranslationAndPurchaseAccountingAdjustments" abstract="false" name="IntangibleAssetsAccumulatedImpairmentTranslationAndPurchaseAccountingAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_BuildingAndEquipmentMember" abstract="true" name="BuildingAndEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_AltriaInvestmentMember" abstract="true" name="AltriaInvestmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_AltriaWarrantMember" abstract="true" name="AltriaWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_PreemptiveRightsMember" abstract="true" name="PreemptiveRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_TopupRightsMember" abstract="true" name="TopupRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_AltriaGroupInc.Member" abstract="true" name="AltriaGroupInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_CronosGroupInc.Member" abstract="true" name="CronosGroupInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_ClassOfWarrantOrRightNumberOfWarrantsIssued" abstract="false" name="ClassOfWarrantOrRightNumberOfWarrantsIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cron_ClassOfWarrantOrRightMinimumOwnershipPercentageRequired" abstract="false" name="ClassOfWarrantOrRightMinimumOwnershipPercentageRequired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="cron_ClassOfWarrantOrRightExercisePriceVolumeWeightedAveragePriceMeasurementPeriod" abstract="false" name="ClassOfWarrantOrRightExercisePriceVolumeWeightedAveragePriceMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cron_ClassOfWarrantOrRightExercisePriceVolumeWeightedAveragePriceMeasurementPeriodDaysPrecedingExercise" abstract="false" name="ClassOfWarrantOrRightExercisePriceVolumeWeightedAveragePriceMeasurementPeriodDaysPrecedingExercise" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cron_DerivativeInstrumentsRollForward" abstract="true" name="DerivativeInstrumentsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cron_PreEmptiveRightsAndTopUpRightsMember" abstract="true" name="PreEmptiveRightsAndTopUpRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_MeasurementInputSubscriptionPriceMember" abstract="true" name="MeasurementInputSubscriptionPriceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_DerivativeLiabilityUsefulLifeTerm" abstract="false" name="DerivativeLiabilityUsefulLifeTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cron_LiabilityClassifiedAwardsMember" abstract="true" name="LiabilityClassifiedAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_A2018StockOptionPlanMember" abstract="true" name="A2018StockOptionPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_A2020OmnibusPlanMember" abstract="true" name="A2020OmnibusPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsWeightedAverageGrantDateFairValue" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="cron_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsForfeitureRate" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsForfeitureRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="cron_A2015StockOptionPlanMember" abstract="true" name="A2015StockOptionPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_DeferredCompensationSharebasedArrangementsLiabilityRollForward" abstract="true" name="DeferredCompensationSharebasedArrangementsLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cron_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssuedInPeriodWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssuedInPeriodWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cron_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssuedInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndIssuedInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cron_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardCliffPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardCliffPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cron_DeferredShareUnitsDSUsMember" abstract="true" name="DeferredShareUnitsDSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_ShareBasedPaymentArrangementLiabilitiesSettled" abstract="false" name="ShareBasedPaymentArrangementLiabilitiesSettled" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_ShareBasedPaymentArrangementGainLossOnRevaluation" abstract="false" name="ShareBasedPaymentArrangementGainLossOnRevaluation" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsAndVestedInPeriod" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsAndVestedInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cron_GinkgoBioworksInc.Member" abstract="true" name="GinkgoBioworksInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_AltriaVenturesInc.Member" abstract="true" name="AltriaVenturesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_ConsultingServicesArrangementMember" abstract="true" name="ConsultingServicesArrangementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_LongtermPurchaseCommitmentEquityInterestIssuedOrIssuableNumberOfShares" abstract="false" name="LongtermPurchaseCommitmentEquityInterestIssuedOrIssuableNumberOfShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cron_LongtermPurchaseCommitmentEquityInterestIssuedOrIssuableValueAssigned" abstract="false" name="LongtermPurchaseCommitmentEquityInterestIssuedOrIssuableValueAssigned" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_LongtermPurchaseCommitmentPaymentsSubjectToMilestones" abstract="false" name="LongtermPurchaseCommitmentPaymentsSubjectToMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_LongtermPurchaseCommitmentMonthlyFeePercentage" abstract="false" name="LongtermPurchaseCommitmentMonthlyFeePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="cron_U.S.DistrictCourtofEasternDistrictofNewYorkVs.CronosMember" abstract="true" name="U.S.DistrictCourtofEasternDistrictofNewYorkVs.CronosMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_OSCSettlementMember" abstract="true" name="OSCSettlementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_GreenLeafVsCronosMember" abstract="true" name="GreenLeafVsCronosMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_CapitalGainRelinquishmentOfWarrant" abstract="false" name="CapitalGainRelinquishmentOfWarrant" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_EffectiveIncomeTaxRateReconciliationExpectedIncomeTaxExpenseRecoveryAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationExpectedIncomeTaxExpenseRecoveryAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseAcquisitionCostsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseAcquisitionCostsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_EffectiveIncomeTaxRateReconciliationFairValueGainFinancialLiabilitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationFairValueGainFinancialLiabilitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_EffectiveIncomeTaxRateReconciliationCapitalGainFinancialLiabilitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationCapitalGainFinancialLiabilitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_EffectiveIncomeTaxRateReconciliationAdditionalTaxableIncomeAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationAdditionalTaxableIncomeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_DeferredTaxAssetsFinanceLeaseLiabilities" abstract="false" name="DeferredTaxAssetsFinanceLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" abstract="false" name="DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cron_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization" abstract="false" name="AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_SignificantExpenses" abstract="false" name="SignificantExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_ContinuingAndDiscontinuedOperationsMember" abstract="true" name="ContinuingAndDiscontinuedOperationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cron_EarningsBeforeInterestTaxesDepreciationAndAmortization" abstract="false" name="EarningsBeforeInterestTaxesDepreciationAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_RestatementReviewExpense" abstract="false" name="RestatementReviewExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_MinistryOfEconomyAndIndustryDumpingInquiryExpense" abstract="false" name="MinistryOfEconomyAndIndustryDumpingInquiryExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_OneMajorCustomerMember" abstract="true" name="OneMajorCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cron_TwoMajorCustomerMember" abstract="true" name="TwoMajorCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cron_ThreeMajorCustomersMember" abstract="true" name="ThreeMajorCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_UnitedStatesSegmentMember" abstract="true" name="UnitedStatesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_RestOfWorldSegmentMember" abstract="true" name="RestOfWorldSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_OneVendorMember" abstract="true" name="OneVendorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_SensitivityAnalysisImpactOf10PercentDecreaseIncreaseInInterestRateOnInterestIncomeNet" abstract="false" name="SensitivityAnalysisImpactOf10PercentDecreaseIncreaseInInterestRateOnInterestIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_SensitivityAnalysisOfCarryingValueNetAssetsImpactOf10PercentChangeInExchangeRate" abstract="false" name="SensitivityAnalysisOfCarryingValueNetAssetsImpactOf10PercentChangeInExchangeRate" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cron_ConsultingServicesMember" abstract="true" name="ConsultingServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_CannabisPurchasesMember" abstract="true" name="CannabisPurchasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_CannabisGermplasmSupplyAgreementMember" abstract="true" name="CannabisGermplasmSupplyAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cron_ManufacturingServicesMember" abstract="true" name="ManufacturingServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_ConsultingArrangementMember" abstract="true" name="ConsultingArrangementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cron_AssetHeldForSaleNotPartOfDisposalGroupSold" abstract="false" name="AssetHeldForSaleNotPartOfDisposalGroupSold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
